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In vitro And In vivo Immunomodulating Properties of Mesenchymal Stem Cells

[ Vol. 12 , Issue. 1 ]

Author(s):

Divya Chaudhary, Raj N. Trivedi, Ashima Kathuria, Tapas K. Goswami, Rekha Khandia and Ashok Munjal*   Pages 59 - 68 ( 10 )

Abstract:


Background: Mesenchymal Stem Cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into all cell types of mesodermal origin, such as adipocytes, osteocytes and chondrocytes. Mesenchymal Stem Cells (MSCs) are adult stem cells which can be isolated from human and animal sources.

Objective: Besides the differentiation potential of MSCs, these also regulate the immune response in numerous ailments. The present review expedites the immunomodulating prospective of MSCs.

Methods: Scrupulous search of the literature and patents available on MSCs and their role in the immunomodulation was carried out using Medline, PubMed, PubMed Central, Science Direct and other scientific databases. The retrieved information has been analyzed and compiled.

Results: MSCs have unique regulation of microenvironment in the host tissue by secreting cytokines and immune-receptors which results in immunomodulatory effects. MSCs can be used as an effective tool in the treatment of chronic diseases because of its property to secrete anti-inflammatory molecules, having multilineage potential and immunomodulation.

Conclusion: The present review is focused on the use of MSCs due to their unique immunomodulatory characteristics. MSCs reach to the site of inflammation and interact with immune cells to bring immunosuppressive and anti-inflammatory effects. Along with these unique therapeutic properties, MSCs may be a useful therapeutic approach for various disorders.

Keywords:

Cytokines, immunomodulation, inflammation, mesenchymal stem cells (MSCs), T-cells, therapeutic properties, Tregs.

Affiliation:

Department of Biotechnology and Microbiology, Meerut Institute of Engineering and Technology, Meerut 250 005, Uttar Pradesh, Department of Veterinary Microbiology, GBPUAT Pantnagar 263 145, Uttrakhand, Department of Biotechnology and Microbiology, Meerut Institute of Engineering and Technology, Meerut 250 005, Uttar Pradesh, Immunology Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243 122, Uttar Pradesh, Department of Biochemistry & Genetics, Barkatullah University, Bhopal 462 026, Madhya Pradesh, Department of Biochemistry & Genetics, Barkatullah University, Bhopal 462 026, Madhya Pradesh



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