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Inhibitors of Phosphoinositol 3 Kinase and NFκB for the Treatment of Chronic Obstructive Pulmonary Disease

[ Vol. 5 , Issue. 3 ]

Author(s):

Nancy E. Larocca, Dolores Moreno, Jenny V. Garmendia and Juan B. De Sanctis   Pages 178 - 183 ( 6 )

Abstract:


Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable disease characterized mainly by pulmonary airflow limitation that is not fully reversible. New different pharmacological approaches to decrease inflammation of the airways and consequently disease progression and increase airway obstruction reversibility have been developed. In the present article, we review the new patents on phosphoinositide 3 kinase and NFκb inhibitors for future therapies.

Keywords:

Alkylamines, azol-pyrimidines derivatives, chronic obstructive pulmonary disease, imidazolines, mTOR inhibitors, NFkb inhibitors, Phosphoinositide 3 kinase, quinazolines, triazoles, spirometry test, lipid kinases, oncogenes

Affiliation:

Insituto de Inmunologia, Facultad de Medicina, Universidad Central de Venezuela, Apartado 50109, Caracas 1050-A, Venezuela.



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