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Dietary Flavonoids: Molecular Mechanisms of Action as Anti- Inflammatory Agents

[ Vol. 5 , Issue. 3 ]

Author(s):

Laura Marzocchella, Massimo Fantini, Monica Benvenuto, Laura Masuelli, Ilaria Tresoldi, Andrea Modesti and Roberto Bei   Pages 200 - 220 ( 21 )

Abstract:


Flavonoids are a large group of polyphenolic compounds, which are ubiquitously expressed in plants. They are grouped according to their chemical structure and function into flavonols, flavones, flavan-3-ols, anthocyanins, flavanones and isoflavones. Many of flavonoids are found in fruits, vegetables and beverages. Flavonoids have been demonstrated to have advantageous effects on human health because their anti-allergic, anti-inflammatory, anti-platelet aggregation, antitumor and anti-oxidant behavior. This report reviews the current knowledge on the molecular mechanisms of action of flavonoids as anti-inflammatory agents and also discusses the relevant patents.

Keywords:

Bioavailability, flavonoids, fruit, inflammation, Flavonols, Flavones, Anthocyanins, pro-inflammatory cytokines, NF-kB activation, Mitogen-Activated-Protein Kinases (MAPKs) signaling

Affiliation:

Department of Experimental Medicine and Biochemical Sciences University of Rome ‘ Tor Vergata’ , Via Montpellier 1, 00133 Rome, Italy.



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